Physician's Choice
Probiotics for Bloating: What Helps, and Why Enzymes Matter
Probiotics and digestive enzymes do different jobs for occasional bloating. A daily probiotic helps support the gut microbiome over time, and a digestive enzyme helps break down the food in the meal you take it with.‡ Because the jobs are different, many people take both, and you can take them on the same day. Physician's Choice pairs the two in the Hack Your Tummy Bundle: 60 Billion Probiotic, 1 capsule a day, and Digestive Enzymes, 1 capsule with your largest meal.
- 60 Billion Probiotic: 60 billion CFU from 10 strains, guaranteed at expiration, with a 150 mg prebiotic blend. Made to support occasional constipation, diarrhea, gas and bloating.‡
- Digestive Enzymes: 16 enzymes in an 85 mg blend, including lactase for dairy and alpha-galactosidase for beans and some vegetables.
- How to take them: the probiotic once a day, with or without food. The enzyme capsule with your largest meal. You can take both with that meal.
- Quality: both are tested by independent labs. 60 Billion Probiotic is made in the USA from imported and domestic ingredients, and Digestive Enzymes is made in the USA in a cGMP-certified facility.
By the Physician's Choice Team. Updated October 8, 2026. Product facts are from the 60 Billion Probiotic and Digestive Enzymes labels, product pages and strain dossier.
Why bloating happens
Most bloating comes from gas. Some of it is air you swallow when you eat and drink. Most of the rest is made in your large intestine, when bacteria there break down carbohydrates that were not fully digested earlier on. That is how the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Cleveland Clinic both describe it.
That gives you two places to look: the meal itself, and the bacteria further down. It is also why two kinds of supplements come up whenever people talk about bloating, digestive enzymes for the first and probiotics for the second. Cleveland Clinic lists probiotics among common over-the-counter options for a bloated stomach.
Probiotics vs digestive enzymes
| Probiotics | Digestive enzymes | |
|---|---|---|
| What they are | Live microorganisms, often called good bacteria | Proteins that break down food |
| What they work on | The bacteria in your gut | The food in the meal you take them with |
| When they work | Over time, with daily use | During that meal |
| How you take ours | 60 Billion Probiotic: 1 capsule a day, with or without food | Digestive Enzymes: 1 capsule with your largest meal |
| What to check on the label | Strain codes, CFU guaranteed at expiration, how it is stored | Which enzymes are listed, and which foods they match |
One does not replace the other. Enzymes help break down the food in a meal, and probiotics help support the gut microbiome over time.‡ If one food always brings on your bloating, start with the enzyme that matches it. Our guide Bloating After Meals: Match the Enzyme to the Food lists which enzyme goes with which food.
Can you take digestive enzymes and probiotics together?
Yes. You can take 60 Billion Probiotic and Digestive Enzymes on the same day, and you can take both with the same meal. A simple routine:
- Take 1 capsule of 60 Billion Probiotic once a day, with or without food. The same time each day is best.
- Take 1 capsule of Digestive Enzymes with your largest meal, just before you eat or with the first few bites.
- If you want both at once, take the probiotic with that same meal.
Some people take one more enzyme capsule with another heavy meal. Most do not go above 2 a day. Timing and storage for both are on our How to Take page. NIDDK advises talking with your doctor before using supplements or probiotics, and that is good advice for any new routine.
What to look for in a probiotic for bloating
Probiotic research is strain-specific: what was found for one strain does not carry over to another, even within the same species. So read the label, not the front of the box. Here is what to check, with what our 60 Billion Probiotic label and strain dossier say.
- Strain codes, not just species. A brand should tell you exactly which strains are inside. 60 Billion Probiotic names all 10 in its strain dossier: Lc-11, La-14, Lpc-37, Ls-33, Lp-115, Bl-04, Bb-06, Bl-05, Bb-18 and Lb-87.
- CFU guaranteed at expiration. A count at manufacture tells you less, because live cultures decline over time. 60 Billion Probiotic guarantees 60 billion CFU at expiration.
- A capsule and bottle built for the trip. It comes in an acid-resistant vegetable capsule, in a bottle that keeps out moisture and light, and needs no refrigeration. More on that in Do Probiotics Need Refrigeration?
- Prebiotic fiber, if you want it. 60 Billion Probiotic includes a 150 mg prebiotic blend of organic inulin from Jerusalem artichoke, organic acacia fiber and organic inulin from chicory. Some people notice a change in gas during the first days of a new probiotic or fiber while the gut adjusts. We cover that in Do Probiotics Cause Gas?
- Independent testing. 60 Billion Probiotic is third-party tested for safety, purity and potency.
- What it is made without. Ours is formulated without dairy, soy, gluten, wheat, peanuts, tree nuts, sesame, eggs, fish, shellfish, color additives, artificial sweeteners and preservatives.
What to look for in a digestive enzyme
- An enzyme list that matches your food. Lactase works on the sugar in dairy. Alpha-galactosidase works on certain carbohydrates in beans, lentils, broccoli and cabbage. Protease, lipase and amylase work on protein, fat and starch. Digestive Enzymes lists all of these among its 16 enzymes.
- Directions tied to meals. Enzymes work on the meal they are taken with, so the label should tell you to take them with food. Ours: 1 capsule with your largest meal.
- Clear cautions. Digestive Enzymes is not recommended for anyone under 18, pregnant or nursing, or taking prescription medication, without talking to a healthcare provider first. It contains enzymes from pineapple and papaya, so check with your provider if you are allergic to either.
The Hack Your Tummy Bundle
If you want both in one order, the Hack Your Tummy Bundle pairs 60 Billion Probiotic with Digestive Enzymes.
When to talk to your healthcare provider
Occasional bloating after a big meal is common. If bloating is persistent, severe, or feels different than usual, talk with your healthcare provider.
Frequently asked questions
Do probiotics help with bloating?
They can, for some people. A probiotic works on the bacteria in your gut over time, so it takes daily use, and results depend on the strains. 60 Billion Probiotic is made to support occasional constipation, diarrhea, gas and bloating.‡
Which is better for bloating, digestive enzymes or probiotics?
They do different jobs. Enzymes work on the food in the meal you take them with. Probiotics help support the gut microbiome over time with daily use.‡ If one food always brings it on, the matching enzyme is the place to start. Many people take both.
Can you take digestive enzymes and probiotics together?
Yes. Take 60 Billion Probiotic once a day, with or without food, and Digestive Enzymes with your largest meal. Since the probiotic can be taken with or without food, you can take both with that meal.
Can a new probiotic cause gas at first?
Some people notice a change in gas during the first days of a new probiotic or prebiotic fiber while the gut adjusts. If it bothers you or lasts, talk with your healthcare provider.
What should I look for in a probiotic for bloating?
Named strain codes, a CFU count guaranteed at expiration, a capsule and bottle that protect the cultures, and independent testing. 60 Billion Probiotic names its 10 strains with codes in its strain dossier and guarantees 60 billion CFU at expiration.
Who should not take digestive enzymes?
Our Digestive Enzymes is not recommended for anyone under 18, pregnant or nursing, or taking prescription medication, without talking to a healthcare provider first. It contains enzymes from pineapple and papaya.
Do probiotics need to be refrigerated?
Not all of them. 60 Billion Probiotic does not need refrigeration. Store it in a cool, dry place.
‡ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Sources: NIDDK, Symptoms and Causes of Gas in the Digestive Tract and Treatment for Gas in the Digestive Tract. Cleveland Clinic, Bloating: What It Is, Causes and When To Be Concerned. Product facts: Physician's Choice labels, product pages and strain dossier.