NatREM is a natural sleep aid that is made from a clinically proven blend of ingredients that promote a restful night’s sleep by targeting anxiety, restlessness, and stress, among other factors that disrupt
sleep. The key ingredient in NatREM is Suntheanine, which is a highly purified form of the essential amino acid L-theanine. Suntheanine has anti-stress and mood enhancing properties [1]. It also demonstrates benefits for those with certain mental health disorders as supplementation with this amino acid is linked to a less anxious mood as well as lower levels of tension and cardiovascular events[2]. More specifically, Suntheanine enhances alpha brain wave activity and this is associated with feeling more relaxed, being more alert, and heightened attention [3]. Furthermore, it appears to promote concentration and learning, support optimal immune system function, and target the negative effects of caffeine [4]. In addition, it has been shown to help improve sleep quality in children with attention-deficit/hyperactivity disorder (ADHD) [5]. By targeting these types of factors, Suntheanine provides numerous health benefits in addition to improving sleep.

Valerian root is another active ingredient. in NatREM. This herb increases the activity of a chemical in the brain called GABA, which promotes relaxation and sleep by slowing down brain activity [6]. In addition, valerian root contains compounds called valepotriates and valeric acid that possess calming
properties [2]. Furthermore, there are amino acids in valerian root which improve sleep quality and target factors that may affect your ability to sleep, such as anxiety and depression [7, 8]. This powerful
herb also induces calmness for people who struggle with hyperactivity or obsessive-compulsive disorder
(OCD) [9, 10].

NatREM also contains a specific type of B vitamin called Pyridoxal-5-Phosphate. This particular B vitamin promotes the conversion of an essential amino acid called tryptophan into serotonin [11]. Serotonin is another chemical in the brain that helps regulate sleep patterns in a manner that is similar to GABA. In addition, the body uses a small amount of serotonin to produce melatonin [12]. Low levels of Pyridoxal-5-Phosphate can disrupt the conversion of tryptophan and this hinders the production of serotonin, which is linked to sleep problems. Chamomile, which is a well-known sleep inducing herb, has also been added to this supplement.

Clinical research shows that chamomile calms the nerves, while targeting anxiety, insomnia, hysteria, nightmares, and additional sleep problems, but it also supports digestive health by relaxing the gastrointestinal tract [13]. This especially versatile herb improves indigestion, motion sickness, nausea, flatulence, stomach cramps, and even muscular pain [13].

Another key ingredient is melatonin, which is a hormone that the body naturally produces and releases into the body at night to encourage sleep [14, 15]. Melatonin supplementation is associated with falling asleep more quickly, an enhanced quality of sleep, and prolonged sleep in the absence of short-term or
long-term health problems. This beneficial hormone also promotes regular sleep, heightens antioxidant activity in the body, and protects nerve cells, especially those involved in maintaining a healthy sleep pattern. Due to its ability to support antioxidants in the body and protect nerve cells, melatonin may
also enhance organ health, the digestive tract, and hormone regulation.

Overall, the specifically chosen ingredients in NatREM target sleep disturbances, insomnia, anxiety, and additional health problems that are linked to restlessness. By taking just two capsules of NatREM, you’ll be able to fall asleep faster, sleep deeper and more peacefully, wake up feeling well rested, and
remained refreshed throughout your day.

Your body will also demonstrate an enhanced ability to regulate anxiety and stress.

References:

1. White DJ, de Klerk S2, et al. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2016;8(1). pii: E53. doi: 10.3390/nu8010053.

2. Kardashev A, Ratner Y, Ritsner MS. Add-On Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial. Clin Schizophr Relat Psychoses. 2018;12(1):31-41.

3. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mentalstate. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.

4. Bukowski JF, Percival SS. L-theanine intervention enhances human gammadeltaT lymphocyte function. Nutr Rev. 2008;66(2):96-102.

5. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-54.

6. Gottesmann C. GABA mechanisms and sleep. Neuroscience. 2002;111(2):231-9.

7. Hadley S, Petry JJ. Valerian. Am Fam Physician. 2003;67(8):1755-8.

8. Salter S, Brownie S. Treating primary insomnia - the efficacy of valerian and
hops. Aust Fam Physician. 2010;39(6):433-7.

9. Gromball J, Beschorner F, et al. Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school children. Phytomedicine. 2014;21(8-9):1098-103.

10. Pakseresht S, Boostani H, Sayyah M. Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. J Complement Integr Med. 2011; 11:8.

11. Zhang, Xiaodong, et al. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science.
2004;305.5681: 217-217.

12. Zawilska JB. The role of calcium in the regulation of melatonin biosynthesis in the retina. Acta Neurobiol Exp (Wars). 1992;52(4):265-74.

13. Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep. 2010;3(6):895-901.

14. Xie Z, Chen F, et al. A review of sleep disorders and melatonin. Neurol Res. 2017;39(6):559-565.

15. Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013;8(5):e63773.

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